Bone Healing Evaluation in Critical-Size Defects Treated with Xenogenous Bone Plus Porcine Collagen
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Data
2017-04-01
Autores
MacIel, Juceléia [UNESP]
Momesso, Gustavo Antonio Correa [UNESP]
Ramalho-Ferreira, Gabriel [UNESP]
Consolaro, Renata Bianco
De Carvalho, Paulo Sérgio Perri [UNESP]
Faverani, Leonardo Perez [UNESP]
Bassi, Ana Paula Farnezi [UNESP]
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Purpose: This study aimed to evaluate the osteoconductive features of Bio-Oss Collagen in large critical-size defects (8 mm). Materials and Methods: Thirty-six adult Wistar Albinus male adult rats were carried out a critical-size defect with a trephine bur of 8 mm in the calvaria. Groups were divided depending on the filling biomaterial as follows: group BO: Bio-Oss (n = 18); group BOC: Bio-Oss Collagen (n = 18). After 7, 30, and 60 days, 6 rats of each group were euthanized with anesthetic overdose. Specimens were laboratory processed for histomorphometric analysis. Histomorphometric data were statistically analyzed by analysis of variance and post-Tukey test (P < 0.05). Results: Statistical differences were found in new bone formation just in the intragroup comparison among periods after 7 and 60 postoperative days, indicating more new bone formation after 60 days (Tukey test, P = 0.029). Conclusion: Under the limitation of this research, it could be concluded that Bio-Oss and Bio-Oss Collagen in this experimental model did not show osteoconductive features.
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biomaterials, calvaria, critical defects, histomorphometric, new bone formation
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Implant Dentistry, v. 26, n. 2, p. 296-302, 2017.