Heterologous fibrin sealant derived from snake venom: From bench to bedside - an overview
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Data
2017-04-04
Autores
Ferreira, Rui Seabra [UNESP]
de Barros, Luciana Curtolo [UNESP]
Abbade, Luciana Patrícia Fernandes [UNESP]
Barraviera, Silvia Regina Catharino Sartori [UNESP]
Silvares, Maria Regina Cavariani [UNESP]
de Pontes, Leticia Gomes [UNESP]
dos Santos, Lucilene Delazari [UNESP]
Barraviera, Benedito [UNESP]
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Resumo
Hemostatic and adhesive agents date back to World War II, when homologous fibrin sealant came onto scene. Considering that infectious diseases can be transmitted via human blood, a new heterologous fibrin sealant was standardized in the 1990s. Its components were a serine protease (a thrombin-like enzyme) extracted from the venom of Crotalus durissus terrificus snakes and a fibrinogen-rich cryoprecipitate extracted from the blood of Bubalus bubalis buffaloes. This new bioproduct has been used as a coagulant, sealant, adhesive and recently as a candidate scaffold for mesenchymal stem cells and bone and cartilage repair. This review discusses the composition of a new heterologous fibrin sealant, and cites published articles related to its preclinical applications aiming at repairing nervous system traumas and regenerating bone marrow. Finally, we present an innovative safety trial I/II that found the product to be a safe and clinically promising candidate for treating chronic venous ulcers. A multicenter clinical trial, phase II/III, with a larger number of participants will be performed to prove the efficacy of an innovative biopharmaceutical product derived from animal venom.
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Buffaloes, Cryoprecipitate coagulum, Fibrin sealant, Snake venom, Thrombin-like enzyme
Como citar
Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 23, n. 1, 2017.