Highlights in nanocarriers for the treatment against cervical cancer
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Data
2017-11-01
Autores
Medina-Alarcón, Kaila P. [UNESP]
Voltan, Aline R.
Fonseca-Santos, Bruno [UNESP]
Moro, Isabela Jacob [UNESP]
de Oliveira Souza, Felipe [UNESP]
Chorilli, Marlus [UNESP]
Soares, Christiane Pienna [UNESP]
dos Santos, André Gonzaga [UNESP]
Mendes-Giannini, Maria J.S. [UNESP]
Fusco-Almeida, Ana M. [UNESP]
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Resumo
Cervical cancer is the second most common malignant tumor in women worldwide and has a high mortality rate, especially when it is associated with human papillomavirus (HPV). In US, an estimated 12,820 cases of invasive cervical cancer and an estimated 4210 deaths from this cancer will occur in 2017. With rare and very aggressive conventional treatments, one sees in the real need of new alternatives of therapy as the delivery of chemotherapeutic agents by nanocarriers using nanotechnology. This review covers different drug delivery systems applied in the treatment of cervical cancer, such as solid lipid nanoparticles (SNLs), liposomes, nanoemulsions and polymeric nanoparticles (PNPs). The main advantages of drug delivery thus improving pharmacological activity, improving solubility, bioavailability to bioavailability reducing toxicity in the target tissue by targeting of ligands, thus facilitating new innovative therapeutic technologies in a too much needed area. Among the main disadvantage is the still high cost of production of these nanocarriers. Therefore, the aim this paper is review the nanotechnology based drug delivery systems in the treatment of cervical cancer.
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Palavras-chave
Cervical cancer, Drug delivery, Gene delivery, Human papillomavirus, Nanocarriers, Nanotechnology
Como citar
Materials Science and Engineering C, v. 80, p. 748-759.