Anti-apoptotic effects of decyl gallate on the induction of apoptosis in A549 pneumocytes by Paracoccidioides brasiliensis gp43
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Data
2017-11-01
Autores
Bernardi, Thais [UNESP]
De Fátima Da Silva, Julhiany [UNESP]
Vicentin, Juliana [UNESP]
De Oliveira, Haroldo Cesar [UNESP]
Assato, Patricia Akemi [UNESP]
Marcos, Caroline Maria [UNESP]
De Paula E Silva, Ana Carolina Alves [UNESP]
Da Silva, Rosangela Aparecida Moraes [UNESP]
Regasini, Luis Octávio [UNESP]
Silva, Dulce Helena Siqueira [UNESP]
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Resumo
Apoptosis is considered an escapemechanism from the host immune system for the fungus Paracoccidioides spp, and it serves as a vehicle for entry into macrophages without stimulating microbicidal activities. Recently, gp43 of P. brasiliensis was demonstrated to be involved in this process. Therefore, as a new therapeutic alternative, it is very important to study compounds that could reduce the modulation of the induction of apoptosis caused by this fungus. Decyl gallate (G14) is a known antifungal compound, and we decided to investigate its anti-apoptotic properties. Our results demonstrate that G14 was effective against apoptosis induced by gp43, as observed in epithelial cells, and led to a reduction in DNA damage, Bak down-regulation and Bcl-2 up-regulation. Together, these data show that G14 presents promising anti-apoptotic activity.
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Apoptosis, Decyl gallate, Gp43, Paracoccidioides brasiliensis
Como citar
Medical Mycology, v. 55, n. 8, p. 890-894, 2017.