“Algae's sulfated polysaccharides modifications: Potential use of microbial enzymes”
Carregando...
Arquivos
Data
2016-08-01
Autores
Gurpilhares, Daniela de Borba
Moreira, Tatiane Rodrigues
Bueno, Julia da Luz
Cinelli, Leonardo Paes
Mazzola, Priscila Gava
Pessoa, Adalberto
Sette, Lara Durães [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
Marine algae are valuable sources of structurally diverse bioactive compounds, among them, the group of sulfated polysaccharides (SPs). As an example of SPs, it could be cited the fucoidans in brown algae, carrageenans in red algae and ulvans in green algae. Since the past decades, SPs have been extracted from algae and evaluated in respect to their beneficial biological activities such as anti-inflammatory, antioxidative, antimicrobial, anticoagulant, antithrombotic, immunological and anticancer. This review deals with the presentation of natively bioactive SPs structural features in addition to already employed approaches of SPs structure modifications, such as chemical and physical methods. Moreover, this article presents the advantages and the importance of using enzymatic methods during SPs modification, and particularly, the use of microorganisms as enzymes sources. Enzymes such as hydrolases/glycosidases (e.g. fucoidanase, fucosidase, agarase and carrageenase), lyases, sulfotransferases and sulfatases could be used for this purpose. It has been shown that more studies are necessary to obtain/identify opportunities to create novel, or to intensify, SPs biological properties. Considering the advantages in the use of microbial enzymes in biotransformation processes, studies related to the modification of SPs by microorganisms should be stimulated.
Descrição
Palavras-chave
Biological activity, Hydrolases, Lyases, Marine algae, Microorganisms, Sulfatases, Sulfotransferases
Como citar
Process Biochemistry, v. 51, n. 8, p. 989-998, 2016.