Gene polymorphisms as a predictor of body weight loss after Roux-en-Y gastric bypass surgery among obese women
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Data
2016-11-01
Autores
Novais, Patrícia Fátima Souza [UNESP]
Weber, Thabata Koester [UNESP]
Lemke, Ney [UNESP]
Verlengia, Rozangela
Crisp, Alex Harley [UNESP]
Rasera-Junior, Irineu
de Oliveira, Maria Rita Marques [UNESP]
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Resumo
This study aimed to investigate the association between twelve gene polymorphisms and body weight loss, 12 months after Roux-en-Y gastric bypass (RYGB) surgery. Three hundred and fifty-one obese women participated in this study. The statistical software WEKA was used to identify which gene polymorphisms were potential predictors of postoperative percentage of excess weight loss (%EWL). Our results indicate that the only gene polymorphism that predicted %EWL was rs3813929, which is related to the serotonin receptor gene (5-HT2C). Therefore, the 5-HT2C gene polymorphism rs3813929 (more specifically, the TT genotype) predicted greater %EWL 12 months after RYGB surgery among female patients.
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Palavras-chave
Bariatric surgery, Gene polymorphism, Obesity, Weight loss
Como citar
Obesity Research and Clinical Practice, v. 10, n. 6, p. 724-727, 2016.