Differentiation potential of mesenchymal stem cells from equine bone marrow cultured on hyaluronic acid-chitosan polyelectrolyte multilayer biofilm

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2016-01-01

Autores

Listoni, Amanda J. [UNESP]
Arruda, Isadora [UNESP]
Maia, Leandro [UNESP]
Barberini, Danielle J. [UNESP]
Martins, Ian [UNESP]
Vasconcellos, Fernando C. [UNESP]
Landim-Alvarenga, Fernanda C. [UNESP]

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Resumo

Nanotechnology techniques have a prominent role in the current technical and scientific scene. The layer-by-layer (LbL) deposition allows obtaining nanostructures with sophisticated multilayer, using a simple, but versatile technique. This procedure, which is used to coat and functionalize surfaces with nanometer - thick films, has applications in bioengineering, medicine, chemistry, materials and chemical engineering among other areas. Chitosan is a biomaterial, coming from the chitin, a very abundant polymer in nature, which has been recently tested as scaffolds. In this experiment we test the hypothesis that the hyaluronic acid-chitosan polyelectrolyte multilayer biofilm would be a good substrate to the adherence of equine mesenchymal stem cells derived from bone marrow. The results showed that these biofilms accelerate the process of cell adhesion on smooth surfaces, allowing a constant cell growth and creating a great option to cover surgical materials.

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Bioengineering, Biofilms, Bone marrow, Chitosan, Hyaluronic acid, Layer-by-layer, Stem cells

Como citar

Stem Cells: Mediated Regeneration, p. 5-16.