Protective effect of resveratrol on urogenital sinus and prostate development in rats exposed in utero to TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin)
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2018-01-01
Autores
Silveira, Lívia Teresa Ribeiro [UNESP]
de Mello Santos, Talita
Camora, Lucas Fredini [UNESP]
Pinho, Cristiane Figueiredo [UNESP]
Anselmo-Franci, Janete A.
Domeniconi, Raquel Fantin
Justulin, Luis Antonio [UNESP]
Barbisan, Luis Fernando [UNESP]
Scarano, Wellerson Rodrigo [UNESP]
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Resumo
This study evaluated the protective effects of resveratrol on the prostate development of rats exposed to TCDD. Pregnant rats received TCDD (1 μg/kg) at GD15 and/or RES (20 mg/kg/day) from GD10 to PND21. Newborn and adult males from Control, TCDD, TCDD + RES and RES groups were euthanized and the prostate was excised. On PND1, there was a reduction in the number of prostatic buds, AR-positive mesenchymal cells and proliferation index in epithelial and mesenchymal cells in TCDD group, but restored by RES. AhR immunoreactivity was greater in TCDD group than the other groups. On PND90, there was higher frequency of functional hyperplasia in the distal area of the prostate acini in TCDD group, but restored by RES. AhRR expression was higher in the TCDD while NRF2 was higher in the TCDD + RES compared to the other groups. Resveratrol was able to reduce the adverse effects of TCDD on prostate development and its long-term repercussions.
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Prostate development, Resveratrol, TCDD, Urogenital sinus
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Reproductive Toxicology.