Phylogenetic analysis reveals a high level of speciation in the Paracoccidioides genus

Nenhuma Miniatura disponível

Data

2009-08-01

Autores

Teixeira, Marcus M.
Theodoro, Raquel C. [UNESP]
Carvalho, Maria J. A. de
Fernandes, Larissa
Paes, Hugo C.
Hahn, Rosane C.
Mendoza, Leonel
Bagagli, Eduardo [UNESP]
San-Blas, Gioconda
Felipe, Maria Sueli S.

Título da Revista

ISSN da Revista

Título de Volume

Editor

Academic Press Inc. Elsevier B.V.

Resumo

Paracoccidioidomycosis (PCM) is a systemic disease endemic to most of Latin America, with greatest impact in rural areas. The taxonomic status of one of the best studied Paracoccidioides isolates (Pb01) as A brasiliensis remains unresolved due to its genomic differences from the other three previously described phylogenetic species (S1, PS2 and PS3; Carrero et al., 2008. Fungal Genet. Biol. 45, 605). Using the genealogic concordance method of phylogenetic species recognition (GCPSR) via maximum parsimony and Bayesian analysis, we identified a clade of 17 genotypically similar isolates, including Pb01, which are distinct from the S1/PS2/P3 clade. Consistent with GCPSR, this "Pb01-like" group can be considered a new phylogenetic species, since it is strongly supported by all independent and concatenated genealogies. "Pb01-like" species exhibit great sequence and morphological divergence from the S1/PS2/PS3 species clade, and we estimate that these groups last shared a common ancestor approximately 32 million years ago. In addition, recombination analysis revealed independent events inside both main groups suggesting reproductive isolation. Consequently, we recommend the formal description of the "Pb01-like" cluster as the new species Paracoccidioides lutzii, a tribute to Adolpho Lutz, discoverer of P. brasiliensis in 1908. (C) 2009 Elsevier B.V. All rights reserved.

Descrição

Palavras-chave

Genealogical concordance, Speciation, Phylogenetic species, Molecular phylogeny, Paracoccidioides brasiliensis, Paracoccidioides lutzii

Como citar

Molecular Phylogenetics and Evolution. San Diego: Academic Press Inc. Elsevier B.V., v. 52, n. 2, p. 273-283, 2009.