Host-guest system of 4-nerolidylcatechol in 2-hydroxypropyl-beta-cyclodextrin: preparation, characterization and molecular modeling
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Data
2009-06-01
Autores
Soares, Lillian Amelia
Vasconcelos Borges Leal, Ana Flavia
Fraceto, Leonardo Fernandes [UNESP]
Maia, Elaine Rose
Resck, Ines Sabioni
Kato, Massuo Jorge
Gil, Eric de Sousa
de Sousa, Aparecido Ribeiro
da Cunha, Luiz Carlos
Rezende, Kennia Rocha
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Editor
Springer
Resumo
The interaction of 4-nerolidylcatechol (4-NRC), a potent antioxidant agent, and 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) was investigated by the solubility method using Fourier transform infrared (FTIR) methods in addition to UV-Vis, (1)H-nuclear magnetic resonance (NMR) spectroscopy and molecular modeling. The inclusion complexes were prepared using grinding, kneading and freeze-drying methods. According to phase solubility studies in water a B(S)-type diagram was found, displaying a stoichiometry complexation of 2:1 (drug:host) and stability constant of 6494 +/- A 837 M(-1). Stoichiometry was established by the UV spectrophotometer using Job's plot method and, also confirmed by molecular modeling. Data from (1)H-NMR, and FTIR, experiments also provided formation evidence of an inclusion complex between 4-NRC and HP-beta-CD. 4-NRC complexation indeed led to higher drug solubility and stability which could probably be useful to improve its biological properties and make it available to oral administration and topical formulations.
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Palavras-chave
4-Nerolidylcatechol, 2-Hydroxypropyl-beta-cyclodextrin, Inclusion complex, (1)H-NMR and molecular dynamics
Como citar
Journal of Inclusion Phenomena and Macrocyclic Chemistry. Dordrecht: Springer, v. 64, n. 1-2, p. 23-35, 2009.