Multichannel AC Biosusceptometry System to Map Biodistribution and Assess the Pharmacokinetic Profile of Magnetic Nanoparticles by Imaging
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Data
2019-07-01
Autores
Soares, Guilherme A. [UNESP]
Prospero, Andre G. [UNESP]
Calabresi, Marcos F. [UNESP]
Rodrigues, Diego S.
Simoes, Luis G. [UNESP]
Quini, Caio C. [UNESP]
Matos, Ronaldo R. [UNESP]
Pinto, Leonardo A. [UNESP]
Sousa-Junior, Ailton A.
Bakuzis, Andris F.
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Resumo
In this paper, the application of a technique to evaluate in vivo biodistribution of magnetic nanoparticles (MNP) is addressed: the Multichannel AC Biosusceptometry System (MC-ACB). It allows real-time assessment of magnetic nanoparticles in both bloodstream clearance and liver accumulation, where a complex network of inter-related cells is responsible for MNP uptake. Based on the acquired MC-ACB images, we propose a mathematical model which helps to understand the distribution and accumulation pharmacokinetics of MNP. The MC-ACB showed a high time resolution to detect and monitor MNP, providing sequential images over the particle biodistribution. Utilizing the MC-ACB instrument, we assessed regions corresponding to the heart and liver, and we determined the MNP transfer rates between the bloodstream and the liver. The pharmacokinetic model resulted in having a strong correlation with the experimental data, suggesting that the MC-ACB is a valuable and accessible imaging device to assess in vivo and real-time pharmacokinetic features of MNP.
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ac biosusceptometry, magnetic imaging, Magnetic nanoparticles, pharmacokinetic model
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IEEE Transactions on Nanobioscience, v. 18, n. 3, p. 456-462, 2019.