Antiproliferative Effect of Urera baccifera Leaves Against Ovarian Carcinoma Cell Line (OVCAR-3)
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Data
2019-01-01
Autores
Benvenutti, Regis Carlos
Gomes, Denise B.
Zanchet, Barbara
Locateli, Gelvani
Dalla Vechia, Cristian Alex
Serpa, Patricia Zanotelli
Lutinski, Junir
Rodrigues Junior, Sinval Adalberto
Schonell, Amanda Patricia
Poletto Diel, Kriptsan Abdon
Título da Revista
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Título de Volume
Editor
Inst Tecnologia Parana
Resumo
Natural products, especially phytochemicals, have been extensively studies and have exhibited important antiproliferative effects. The American native species Urera baccifera (L.) Gaudich. ex Wedd. (Urticaceae) is widely distributed in Brazil, where it is known as urtiga-vermelha or urtigao. The leaves are popularly used as anti-inflammatory, antirheumatic and in the treatment of gastric disorders. However, the antiproliferative potential of this plant against human tumor cells remain to be elucidated. In this study, we evaluated the antiproliferative effects of U. baccifera leaves extracts and fractions against a panel of human tumor cell lines in vitro besides a chemical evaluation of the most active sample by mass spectrometry (ESI-IT-MSn). The hydroalcoholic extract was inactive while dichloromethane extract showed moderate cytostatic activity against ovarian carcinoma cell line (OVCAR-3, GI(50) = 1.5 mu g/mL). More, the ethyl acetate and n-butanol fractions did not show important activity against tumour cell while the dichloromethane and hexane fractions showed moderate cytostatic activity against ovarian tumor cell line (OVCAR-3, GI(50) = 12.7 and 9.4 mu g/mL, respectively). Finally, the chemical profile evaluated by mass spectrometry (ESI-IT-MSn) allowed the detection of flavonoids in the HEU and hydroxylated fatty acid in DEU that can explain partially the biological effects observed. This is the first report of the antiproliferative effects of U. baccifera, and DEU has shown potential as a promising source of bioactive compounds.
Descrição
Palavras-chave
antitumor agents, medicinal plants, chemical analysis
Como citar
Brazilian Archives Of Biology And Technology. Curitiba-parana: Inst Tecnologia Parana, v. 62, 12 p., 2019.