Human platelet antigen-3 polymorphism as a risk factor for rheumatological manifestations in hepatitis C
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Data
2020-01-01
Título da Revista
ISSN da Revista
Título de Volume
Editor
Soc Brasileira Medicina Tropical
Resumo
Introduction: Hepatitis C virus (HCV) infection is involved in the pathogenesis of autoimmune and rheumatic disorders. Although the human platelet antigens (HPA) polymorphism are associated with HCV persistence, they have not been investigated in rheumatological manifestations (RM). This study focused on verifying associations between allele and genotype HPA and RM in patients with chronic hepatitis C. Methods: Patients (159) with chronic hepatitis C of both genders were analyzed. Results: Women showed association between HPA-3 polymorphisms and RM. Conclusions: An unprecedented strong association between rheumatological manifestations and HPA-3 polymorphism, possibly predisposing women to complications during the disease course, was observed.
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Palavras-chave
Hepatitis C, Human platelet antigens, Polymorphism, Rheumatological manifestations
Como citar
Revista Da Sociedade Brasileira De Medicina Tropical. Brasilia: Soc Brasileira Medicina Tropical, v. 53, 4 p., 2020.