Assessment of the hypoglycemic effect of Bixin in alloxan-induced diabetic rats: in vivo and in silico studies
Nenhuma Miniatura disponível
Data
2020-02-12
Autores
Keita, Hady
Santos, Cleydson Breno Rodrigues dos
Ramos, Matheus Merces
Padilha, Elias Carvalho [UNESP]
Serafim, Rodolfo Bortolozo
Castro, Andres Navarrete
Amado, Jesus Rafael Rodriguez
Silva, Gabriel Monteiro da
Ferreira, Irlon Maciel
Giuliatti, Silvana
Título da Revista
ISSN da Revista
Título de Volume
Editor
Taylor & Francis Inc
Resumo
The objectives of this study were to extract and purify Bixin from the seeds of Bixa orellana and to evaluate its hypoglycemic activity in vivo, as well as, to conduct an in silico study of selectivity on peroxisome proliferator-activated receptors via molecular docking and molecular dynamics simulations. Oral administration of Bixin (10 mg/kg) significantly reduced their glucose level that was alloxan-induced diabetic rats. Bixin showed in silico selectivity on peroxisome proliferator-activated receptors (PPARs), particularly by the peroxisome proliferator-activated receptor gamma (PPAR gamma), which supports the hypoglycemic activity of Bixin. From the results obtained, it can be inferred that Bixin presents hypoglycemic characteristics, which was confirmed by the results obtained from the in vivo and in silico tests. Bixin may act by other pathways to control blood glucose and thus it is possible that it presents a different toxicity profile than troglitazone, rosiglitazone and pioglitazone. However, more studies on the activity and toxicity of Bixin are needed to evaluate for further clinical use.
Descrição
Palavras-chave
Bixin, hypoglycemia, PPAR gamma, in vivo, in silico
Como citar
Journal Of Biomolecular Structure & Dynamics. Philadelphia: Taylor & Francis Inc, 12 p., 2020.