A new scenario of bioprospecting of Hymenoptera venoms through proteomic approach

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Data

2011-01-01

Autores

Santos, L. D. [UNESP]
Pieroni, M.
Menegasso, A. R. S. [UNESP]
Pinto, J. R. A. S. [UNESP]
Palma, Mario Sergio [UNESP]

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Editor

Universidade Estadual Paulista (Unesp), Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP)

Resumo

Venoms represent a huge and essentially unexplored reservoir of bioactive components that may cure diseases that do not respond to currently available therapies. This review select advances reported in the literature from 2000 to the present about the new scenario of Hymenoptera venom composition. on account of new technologies in the proteomic approach, which presents high resolution and sensitivity, the combination of developments in new instruments, fragmentation methods, strategic analysis, and mass spectrometry have become indispensable tools for interrogation of protein expression, molecule interaction, and post-translational modifications. Thus, the biochemical characterization of Hymenoptera venom has become a major subject of research in the area of allergy and immunology, in which proteomics has been an excellent alternative to assist the development of more specific extracts for diagnosis and treatment of hypersensitive patients to Hymenoptera venoms.

Descrição

Palavras-chave

hymenoptera, venoms, allergens, phospholipase A1, wasp venom antigen 5, hyaluronoglucosaminidase, mass spectrometry, proteomics

Como citar

Journal of Venomous Animals and Toxins Including Tropical Diseases. Botucatu: Cevap-unesp, v. 17, n. 4, p. 364-377, 2011.