Publicação: Nitroheterocyclic derivatives: privileged scaffold for drug development against Chagas disease
Carregando...
Data
Autores
Orientador
Coorientador
Pós-graduação
Curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Editor
Tipo
Resenha
Direito de acesso
Resumo
Chagas disease or American trypanosomiasis is a major public health problem in Latin America. Approximately seven million people are currently infected worldwide. Despite the efforts to develop new drugs, only two nitroheterocyclic drugs (nifurtimox and benznidazole) are available for the treatment of Chagas disease, These drugs have been available since the 1970s, and no new drugs have been approved. Due to the lack of alternatives for the treatment of this disease, this review describes recent advances (2013–2019) concerning nitroheterocyclic compounds with activity against T. cruzi parasites, as well as new perspectives for future research.
Descrição
Palavras-chave
Chagas disease, New drugs, Nitro compounds, T. cruzi
Idioma
Inglês
Como citar
Medicinal Chemistry Research, v. 28, n. 12, p. 2099-2108, 2019.
