Polybioside, a Neuroactive Compound from the Venom of the Social Wasp Polybia paulista
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Data
2010-04-01
Autores
Saidemberg, Daniel M. [UNESP]
da Silva-Filho, Luiz C. [UNESP]
Cesar Tognoli, Lilian M. M. [UNESP]
Tormena, Claudio F.
Palma, Mario Sergio [UNESP]
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Amer Chemical Soc
Resumo
Polybioside (1) was isolated from the venom of the social wasp Polybia paulista, and its structure was assigned as 3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl 3-(1H-imidazol-4-yl)propanimidate by NMR and MS protocols. The application of polybioside in rat brain, followed by the detection of c-Fos protein expression in some brain regions, indicated the compound is neuroactive in a number of brain areas. Polybioside causes convulsions in rats, even when peripherally applied.
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Journal of Natural Products. Washington: Amer Chemical Soc, v. 73, n. 4, p. 527-531, 2010.