Acetylcholinesterase inhibition and antifungal activity of cyclohexanoids from the endophytic fungus Saccharicola sp.
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Data
2020-10-01
Autores
Chapla, Vanessa M.
Honório, Alana E. [UNESP]
Gubiani, Juliana R.
Vilela, Adriana F.L.
Young, Maria C.M.
Cardoso, Carmen L.
Pavan, Fernando R. [UNESP]
Cicarelli, Regina M. [UNESP]
Michel Pinheiro Ferreira, Paulo
Bolzani, Vanderlan da S. [UNESP]
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Resumo
Three new oxygenated cyclohexanoids, namely, speciosin U (1), speciosin V (2) and speciosin W (3), along with four known compounds consisting of 4-hydroxy-3-(3′-methylbut-3′-en-1′-ynyl)-benzoic acid (4), 4-hydroxy-3-prenyl-benzoic acid (5), 2,2-dimethyl-2H-chromene-6-carboxylic acid (6) and trans-3,4-dihydro-3,4-dihydroxy-anofinic acid (7) were isolated from scale-up cultures of Saccharicola sp., an endophyte of Eugenia jambolana. The structures were established by analysis of spectroscopic data, including 1D and 2D NMR. The absolute configuration of 1 was determined using Mosher's method. Speciosin U (1) and trans-3,4-dihydro-3,4-dihydroxy-anofinic acid (7) exhibited a potent acetylcholinesterase (AChE) inhibitory activity comparable to reference inhibitor galantamine. Furthermore, speciosin U (1) presented antifungal activity invitro against the phytopathogenic fungi Cladosporium cladosporioides, while compounds 4-hydroxy-3-(3′-methylbut-3′-en-1′-ynyl)-benzoic acid (4) and 4-hydroxy-3-prenyl-benzoic acid (5) exhibited antifungal activity against C. sphaerospermum.
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Palavras-chave
AchE inhibitory activity, Cyclohexanoids, Endophytic fungi, Eugenia jambolana, Saccharicola sp., Speciosins
Como citar
Phytochemistry Letters, v. 39, p. 116-123.