Câncer de Cólon, Taurina e Análise Histopatológica : Uma Revisão
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Data
2021-12-16
Autores
Santa Catharina, Fernando
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Editor
Universidade Estadual Paulista (Unesp)
Resumo
O câncer de cólon retal (CCR) é um dos 10 tipos de câncer mais incidentes do mundo, causando quase 10 milhões de mortes somente em 2018. Nos últimos 3 anos houve aumento de 10% na mortalidade causada por CCR, demonstrando que os tratamentos existentes não são totalmente eficazes, devido a não eficácia, toxicidade ou não adesão. A terapia consiste na remoção cirúrgica do tumor e em alguns casos a quimioterapia adjuvante, composta de 5-fluorouacil (5-FU), e outros fármacos associados. A taurina é um aminoácido semi-essencial com potente atividade antioxidante, antimutagênica e anti-inflamatória, capaz de promover proteção cardíaca e renal frente a toxicidade tecidual causada por quimioterápicos como a doxorrubicina e cisplatina. Estudos realizados no Lapdesf demonstraram que a taurina foi capaz de reduzir o CCR induzido quimicamente em animais e potencializar o efeito do 5FU. O presente trabalho tinha como objetivo, o estudo imuno-histoquimico para a elucidação dos marcadores envolvidos no estudo da tauri na/5FU/CCR. Entretanto, devido à pandemia da Covid-19, impediu a finalização experimental da pesquisa. Assim, presente trabalho foi transformado em uma revisão bibliográfica, envolvendo a CCR, genes envolvidos na CCR, diagnóstico (atualização da literatura sobre os métodos imunohistoquimicos) e taurina. Assim, para a revisão, foram utilizadas as palavras-chaves câncer de colon, genes, diagnostico, imunohistoquimica, taurina e a busca no banco de dados Pubmed, Lilacs, entre os períodos de 2000 - 2021.
Rectal colon cancer (RCC) is one of the 10 most common types of cancer in the world, causing almost 10 million deaths in 2018 alone. In the last 3 years there has been a 10% increase in mortality caused by RCC, demonstrating that the existing treatments are not fully effective, due to non-efficacy, toxicity or non-adherence. The therapy consists of surgical removal of the tumor and in some cases adjuvant chemotherapy, composed of 5-fluorouacil (5-FU), and other associated drugs. Taurine is a semi-essential amino acid with powerful antioxidant, antimutagenic and anti-inflammatory activity, capable of promoting cardiac and renal protection against tissue toxicity caused by chemotherapics such as doxorubicin and cisplatin. Studies conducted at Lapdesf demonstrated that taurine was able to reduce chemically induced RCC in animals and enhance the effect of 5-FU. The present work had as objective, the immunohistochemical study for the elucidation of the markers involved in the taurine/5FU/RCC study. However, due to the Covid-19 pandemic, it prevented the experimental completion of the research. Thus, this study was changed into a literature review about RCC, including genes involved in RCC, diagnosis (update of the literature on immunohistochemical methods) and taurine. Thus, for the review, it was used the key words colon cancer, genes, diagnosis, immuno histochemistry, taurine in the Pubmed and Lilacs database, between periods 2000 - 2021.
Rectal colon cancer (RCC) is one of the 10 most common types of cancer in the world, causing almost 10 million deaths in 2018 alone. In the last 3 years there has been a 10% increase in mortality caused by RCC, demonstrating that the existing treatments are not fully effective, due to non-efficacy, toxicity or non-adherence. The therapy consists of surgical removal of the tumor and in some cases adjuvant chemotherapy, composed of 5-fluorouacil (5-FU), and other associated drugs. Taurine is a semi-essential amino acid with powerful antioxidant, antimutagenic and anti-inflammatory activity, capable of promoting cardiac and renal protection against tissue toxicity caused by chemotherapics such as doxorubicin and cisplatin. Studies conducted at Lapdesf demonstrated that taurine was able to reduce chemically induced RCC in animals and enhance the effect of 5-FU. The present work had as objective, the immunohistochemical study for the elucidation of the markers involved in the taurine/5FU/RCC study. However, due to the Covid-19 pandemic, it prevented the experimental completion of the research. Thus, this study was changed into a literature review about RCC, including genes involved in RCC, diagnosis (update of the literature on immunohistochemical methods) and taurine. Thus, for the review, it was used the key words colon cancer, genes, diagnosis, immuno histochemistry, taurine in the Pubmed and Lilacs database, between periods 2000 - 2021.
Descrição
Palavras-chave
câncer de cólon, genes, diagnóstico, Imuno-histoquímica, taurina, diagnosis, Immunohistochemistry, Taurine