Publicação: Spectrophotometric determination of acetazolamide using a flow injection system with KMnO4 reagent
Carregando...
Data
Orientador
Coorientador
Pós-graduação
Curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Editor
Tipo
Artigo
Direito de acesso
Resumo
A flow injection spectrophotometric method was developed for the determination of acetazolamide, (N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide), in commercial anti-hypertensive drugs. The new and simple procedure is based on the reaction between sulfonamide groups and permanganate ions in an alkaline medium. The results showed that linear quantification of acetazolamide could be achieved at two wavelengths. A decrease of the permanganate concentration could be measured at 530 nm, while an increase in manganate concentration could be measured at 610 nm, in the concentration ranges from 1.0 × 10-5 to 2.5 × 10-4 mol L-1 and from 2.5 × 10-5 to 2.5 × 10-4 mol L-1, respectively. The detection limits were 4.5 × 10-6 mol L-1 (530 nm) and 2.2 × 10-6 mol L-1 (610 nm). The usual excipients used in commercial drugs did not interfere in the determinations, and the results were consistent with those obtained by a UV reference technique.
Descrição
Palavras-chave
Acetazolamide, Flow injection, Permanganate, Spectrophotometric determination
Idioma
Inglês
Como citar
Brazilian Journal of Analytical Chemistry, v. 3, n. 9, p. 374-379, 2012.
