Magnetically drivable nano-bio-conjugate mimicking free Curcumin redox behavior
Nenhuma Miniatura disponível
Data
2013-01-01
Autores
Magro, Massimiliano
Campos, Rene [UNESP]
Baratella, Davide
Pace Pereira Lima, Giuseppina [UNESP]
Zboril, Radek
Vianello, Fabio
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
Curcumin possesses wide-ranging anti-inflammatory and anti-cancer properties and its biological activity can be correlated to its potent antioxidant capacity. Novel maghemite (?-Fe<inf>3</inf>O<inf>4</inf>) nanoparticles, characterized by a diameter of about 10 nm and possessing peculiar colloidal properties and surface interactions, called Surface Active Maghemite Nanoparticles (SAMN), were superficially modified with curcumin by simple incubation, due to the presence of under-coordinated Fe(III) atoms on nanoparticle surface. The resulting curcumin-modified SAMNs (SAMN@curcumin) were characterized by transmission electron microscopy (TEM), FTIR, Mossbauer, EPR and UV-Vis spectroscopy. The redox properties of bound curcumin were tested by electrochemistry. Finally, SAMN@curcumin was studied in the presence of different electroactive substances, namely hydroquinone, NADH and ferrocyanide, in order to assess its electrochemical behavior. Moreover, SAMN@curcumin was electrochemically tested in the presence of one of the most diffuse reactive oxygen specie, such as hydrogen peroxide, demonstrating its stability. SAMN@curcumin in which curcumin is firmly bound, but still retaining its redox features represents a feasible adduct: a magnetically drivable nano-bio-conjugate mimicking free Curcumin redox behavior. The proposed nanostructured material could be exploited as magnetic drivable curcumin vehicle for biomedical applications.
Descrição
Palavras-chave
Curcumin, Hydrogen peroxide, Maghemite nanoparticles, NADH oxidation, Nanomaterial electrocatalysis
Como citar
NANOCON 2013 - Conference Proceedings, 5th International Conference, p. 654-658.