ZIKV B-cell epitopes for immunodiagnostic tests
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Data
2022-05-01
Autores
Kubiszeski, Janaina Rigotti
da Silva, David José Ferreira
Menezes, Gabriela de Lima
da Silva, Roosevelt Alves
Zini, Nathalia
Nogueira, Maurício Lacerda
Pena, Lindomar José
Piccoli, Julia Pinto
Cilli, Eduardo Maffud
da Silva, Joaquim Manoel
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The use of serological tests is valuable to diagnose Zika virus (ZIKV) infection and carry out epidemiological surveillance. However, ZIKV serological tests may result in false positives due to cross-reactivity between antibodies against other Flavivirus, especially dengue virus that worldwide disseminated. We used three online tools to predict amino acid sequences of B-cell epitopes. We selected and synthetized two epitopes that showed appropriate features in the molecular dynamic simulation and demonstrated to be suitable for serological assays.
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Arbovirus, Bioinformatics, Immunoassay, Peptide
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Journal of Immunological Methods, v. 504.