Cholecystokinin actions in the parabrachial nucleus: Effects on thirst and salt appetite
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Data
1998-01-01
Autores
Menani, Jose Vanderlei [UNESP]
Johnson, Alan Kim
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Resumo
The present study investigated the effects of bilateral injections of the nonselective CCK receptor antagonist proglumide or CCK-8 into the lateral parabrachial nuclei (LPBN) on the ingestion of 0.3 M NaCl and water induced by intracerebroventricular injection of ANG II or by a combined treatment with subcutaneous furosemide (Furo) + captopril (Cap). Compared with the injection of saline (vehicle), bilateral LPBN injections of proglumide (50 μg · 200 nl-1 · site-1) increased the intake of 0.3 M NaCl induced by intracerebroventricular ANG II (50 ng/l μl). Bilateral injections of proglumide into the LPBN also increased ANG II-induced water intake when NaCl was simultaneously available, but not when only water was present. Similarly, the ingestion of 0.3 M NaCl and water induced by the treatment with Furo (10 mg/kg) + Cap (5 mg/kg) was increased by bilateral LPBN proglumide pretreatment. Bilateral CCK-8 (0.5 μg · 200 nl-1 · site-1) injections into the LPBN did not change Furo + Cap-induced 0.3 M NaCl intake but reduced water consumption. When only water was available after intracerebroventricular ANG II, bilateral LPBN injections of proglumide or CCK-8 had no effect or significantly reduced water intake compared with LPBN vehicle-treated rats. Taken together, these results suggest that CCK actions in the LPBN play a modulatory role on the control of NaCl and water intake induced by experimental treatments that induce hypovolemia and/or hypotension or that mimic those states.
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Proglumide, Sodium appetite, Sodium chloride intake, Water intake
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American Journal of Physiology - Regulatory Integrative and Comparative Physiology, v. 275, n. 5 44-5, 1998.