Ausência de associação entre os polimorfismos do gene interleucina-18 e artrite reumatoide
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Data
2013-01-01
Autores
Farias, Ticiana Della Justina
Do Cantoa, Luisa Matos
Medeiros, Mayara Delagnelo
Sereia, Aline Fernanda Rodrigues
Back, Lia Kubelka Fernandes de Carlos
De Mello, Filipe Martins
Zimmermann, Adriana Fontes
Pereira, Ivânio Alves
Muniz, Yara Costa Netto
Marrero, Andrea Rita
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Resumo
Objective: To assess the association of the polymorphisms of the interleukin-18 (IL-18) gene with rheumatoid arthritis (RA) and with risk factors for cardiovascular diseases (CVD). Methods: This sample comprised 97 patients with RA and 151 healthy controls. In the patients, risk factors for CVD were analyzed, such as cholesterol levels, arterial hypertension, smoking habit, C-reactive protein (CRP) level, and rheumatoid factor. DNA was extracted and the single nucleotide polymorphisms (SNP) at the -607C/A and -137G/C positions of the IL-18 gene were assessed in both groups. The Hardy-Weinberg equilibrium (HWE) was calculated and the odds ratio (OR) test performed, considering a 95% CI and P < 0.05. Results: The frequencies of the -607A allele in patients with RA and in controls were 0,443 and 0.424, respectively, and of the -137C allele, 0.304 and 0.291, respectively. The genotype frequencies were in HWE, except for controls in the -137 locus (P = 0.006). Association of the polymorphisms of the IL-18 gene was found with neither RA nor risk factors for CVD, including cholesterol level and CRP (P > 0.05). In addition, more smokers were found among patients with RA as compared with controls (OR = 1.691; P = 0.088), and the CRP levels were slightly higher in patients who smoked than in patients who did not (OR = 2.673; P = 0.061). Conclusions: In this sample of patients with RA in the South of Brazil, association of the polymorphisms of the IL-18 gene was observed with neither RA nor risk factors for CVD. ©2013 Elsevier Editora Ltda.
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Brazil, Cardiovascular diseases, Gene polymorphism, Interleukin-18, Rheumatoid arthritis
Como citar
Revista Brasileira de Reumatologia, v. 53, n. 2, p. 199-205, 2013.