A multi-screening approach for marine-derived fungal metabolites and the isolation of cyclodepsipeptides from Beauveria felina
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Data
2008-01-01
Autores
Vita-Marques, Aline Maria de
Lira, Simone P.
Berlinck, Roberto G. S.
Seleghim, Mirna H. R.
Sponchiado, Sandra R. P. [UNESP]
Tauk-Tornisielo, Sâmia M. [UNESP]
Barata, Margarida
Pessoa, Claudia
Moraes, Manoel O. de
Cavalcanti, Bruno Coêlho
Título da Revista
ISSN da Revista
Título de Volume
Editor
Sociedade Brasileira de Química
Resumo
Extracts obtained from 57 marine-derived fungal strains were analyzed by HPLC-PDA, TLC and ¹H NMR. The analyses showed that the growth conditions affected the chemical profile of crude extracts. Furthermore, the majority of fungal strains which produced either bioactive of chemically distinctive crude extracts have been isolated from sediments or marine algae. The chemical investigation of the antimycobacterial and cytotoxic crude extract obtained from two strains of the fungus Beauveria felina have yielded cyclodepsipeptides related to destruxins. The present approach constitutes a valuable tool for the selection of fungal strains that produce chemically interesting or biologically active secondary metabolites.
Descrição
Palavras-chave
marine-derived fungi, screening, Beauveria felina
Como citar
Química Nova. Sociedade Brasileira de Química, v. 31, n. 5, p. 1099-1103, 2008.