Determination of 5-aminosalicylic acid in pharmaceutical formulations by square wave voltammetry at pencil graphite electrodes
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Data
2010-01-01
Autores
Uliana, Carolina V. [UNESP]
Yamanaka, Hideko [UNESP]
Garbellini, Gustavo S.
Salazar-Banda, Giancarlo R.
Título da Revista
ISSN da Revista
Título de Volume
Editor
Sociedade Brasileira de Química
Resumo
An analytical method for the determination of the anti-inflammatory drug 5-aminosalicylic acid (5-ASA) in pharmaceutical formulations using square wave voltammetry at pencil graphite electrodes was developed. After the optimization of the experimental conditions, calibration curves were obtained in the linear concentration range from 9.78 × 10-7 to 7.25 × 10-5 mol L-1 resulting in a limit of detection of 2.12 ± 0.05 x 10-8 mol L-1. Statistical tests showed that the concentrations of 5-ASA in commercial tablets and enemas obtained with the proposed voltammetric method agreed with HPLC values at a 95% confidence level.
Descrição
Palavras-chave
5-aminosalicylic acid, pharmaceutical formulations, pencil graphite electrode
Como citar
Química Nova. Sociedade Brasileira de Química, v. 33, n. 4, p. 964-967, 2010.