Cytotoxic Clerodane Diterpenoids from Casearia obliqua
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Data
2009-10-01
Autores
Vieira Junior, Gerardo Magela [UNESP]
Goncalves, Tiago de Oliveira [UNESP]
Regasini, Luis O. [UNESP]
Pinheiro Ferreira, Paulo M.
Pessoa, Claudia do O.
Costa Lotufo, Leticia V.
Torres, Roseli Buzanelli
Boralle, Nivaldo [UNESP]
Bolzani, Vanderlan da Silva [UNESP]
Cavalheiro, Alberto José [UNESP]
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Amer Chemical Soc
Resumo
A crude bioactive EtOH extract of the twigs of Casearia obliqua afforded two new clerodane diterpenes, caseobliquins A (1) and B (2). Additionally, bioactivity-directed fractionation on a bioactive hexane extract of the leaves from this species led. to the isolation of the known clerodane diterpenes rel-6 beta-hydroxyzuelanin-2 beta-benzoate and rel-2 alpha-hydroxyzuelanin-6 beta-benzoate (3 and 4) as a mixture and 2 beta-hydroxyzuelanin-6 beta-cinnamate (5). The structures of the new clerodanes 1 and 2 were established on the basis of their 1D and 2D NMR spectroscopic data, and the new compound I and the known substance 5 had their absolute configurations determined by circular dichroism spectroscopy. The cytotoxicity of several of the compounds isolated was evaluated against a small panel of human tumor cell lines.
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Journal of Natural Products. Washington: Amer Chemical Soc, v. 72, n. 10, p. 1847-1850, 2009.