Study of Salmonella typhimurium mutagenicity assay of (E)-piplartine by the Ames test
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Data
2011-06-15
Autores
Morandim-Giannetti, Andreia de A.
Cotinguiba, Fernando
Regasini, Luis O.
Frigieri, Mariana C. [UNESP]
Varanda, Eliana Aparecida [UNESP]
Coqueiro, Aline
Kato, Massuo J.
Bolzani, Vanderlan da Silva [UNESP]
Furlan, Maysa [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Academic Journals
Resumo
Phytochemical studies carried out with Piperaceae species have shown great diversity of secondary metabolites among which are several displayed considerable biological activities. The species Piper tuberculatum has been intensively investigated and a series of amides have been described. For instance, (E)-piplartine showed significant cytotoxic activity against tumor cell lines, especially human leukemia cell lines; antifungal activity against Cladosporium species; trypanocidal activity and others. Considering the popular use of P. tuberculatum and the lack of pharmacological studies regarding this plant species, the mutagenic and antimutagenic effect of (E)-piplartine was evaluated by the Ames test, using the strains TA97a, TA98, TA100 and TA102 of Salmonella typhimurium. No mutagenic activity was observed for this compound.
Descrição
Palavras-chave
Piperaceae, Piper tuberculatum, (Z)-piplartine, mutagenic activated, Ames test
Como citar
African Journal of Biotechnology. Victoria Island: Academic Journals, v. 10, n. 27, p. 5398-5401, 2011.