Desenvolvimento de um método reflectométrico ambientalmente mais amigável para a determinação de metoclopramida em formulações farmacêuticas
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Data
2010-01-01
Autores
Doretto, Keity Margareth [UNESP]
Gotardo, Mara Andréia [UNESP]
Pezza, Helena Redigolo [UNESP]
Pezza, Leonardo [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Sociedade Brasileira de Química
Resumo
A simple and more environmentally friendly method by combined spot test-diffuse reflectance spectroscopy for determining metoclopramide in pharmaceutical formulations is described. The method is based on the reaction between metoclopramide and p-dimethylaminocinnamaldehyde, in the presence of HCl, producing a colored compound (λmáx = 580 nm) on the filter paper. The linear range was from 5.65 x 10-4-6.21x10-3 mol L-1 (r = 0.999). The limit of detection was 1.27 x 10-4 mol L-1. The proposed reflectometric method was applied successfully to the determination of metoclopramide in pharmaceuticals and it was favorably compared with the Brazilian or British Pharmacopoeia methods at 95% confidence level.
Descrição
Palavras-chave
diffuse reflectance spectroscopy, metoclopramide, spot test
Como citar
Química Nova. Sociedade Brasileira de Química, v. 33, n. 2, p. 461-465, 2010.