Antimicrobial activity of Piper arboreum and Piper tuberculatum (Piperaceae) against opportunistic yeasts
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Data
2009-06-17
Autores
Regasini, Luis Octavio [UNESP]
Cotinguiba, Fernando [UNESP]
Morandim, Andreia de Araujo [UNESP]
Kato, Massuo Jorge [UNESP]
Scorzoni, Liliana [UNESP]
Mendes-Giannini, Maria José Soares [UNESP]
Bolzani, Vanderlan da Silva [UNESP]
Furlan, Maysa [UNESP]
Título da Revista
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Título de Volume
Editor
Academic Journals
Resumo
In the scope of our ongoing research on bioactive agents from natural sources, 24 extracts and fractions obtained from Piper arboreum Aub. and Piper tuberculatum Jacq. ( Piperaceae) were screened for antifungal activity by using broth microdilution method. The current investigation reveals that P. arboreum extracts and fractions were more effective against Candida krusei and Candida parapsilosis than Cryptococcus neoformans. The growth of Candida albicans was weakly affected by all the tested extracts and fractions. The strongest effects were observed for hexane and ethyl acetate fractions from leaves of P. arboreum, with MIC values ( in mu g/ml) of 15.6 and 31.2 mu g/ml against C. krusei, respectively. Additionally, phytochemical investigation of the hexane fraction of P. arboreum leaves furnished 3 pyrrolidine amides; piperyline, 4,5-dihydropiperyline and tetrahydropiperyline, which could be responsible, at least in part for the observed antifungal activity. The most active compound, tetrahydropiperyline, displayed MIC values of 15.6 mu g/ml against C. krusei, C. parapsilosis and C. neoformans.
Descrição
Palavras-chave
Antifungal, antimicrobial, Piper arboreum, Piper tuberculatum, Piperaceae, Candida, Cryptococcus neoformans
Como citar
African Journal of Biotechnology. Victoria Island: Academic Journals, v. 8, n. 12, p. 2866-2870, 2009.