Spectrophotometric determination of dipyrone in pharmaceutical preparations by using chromotropic acid
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Data
1999-09-30
Autores
Sakiara, K. A.
Pezza, Leonardo [UNESP]
Melios, C. B.
Pezza, Helena Redigolo [UNESP]
de Moraes, M.
Título da Revista
ISSN da Revista
Título de Volume
Editor
Elsevier B.V.
Resumo
A spectrophotometric method for the determination of dipyrone in pharmaceutical preparations is proposed. This method is based on selective oxidation of dipyrone, in the presence of sulphuric acid, splitting off formaldehyde which reacts with chromotropic acid, also in a sulphuric acid medium, producing a violet-red compound (lambda(max) 575 nm). Beer's law is obeyed in a concentration range of 0.57-5.7 ppm dipyrone with an excellent correlation coefficient (r = 0.9997). The results show a simple, accurate, selective and readily applied method to the determination of dipyrone in pharmaceutical products. The analytical results obtained for these products by the proposed method are in agreement with those of the Brazilian Pharmacopoeia procedure. No interference was observed from common excipients in formulations. Recoveries were within 98.7-101.2%, with standard deviations ranging from 0.2 to 1.7%. (C) 1999 Elsevier B.V. S.A. All rights reserved.
Descrição
Palavras-chave
dipyrone, chromotropic acid, spectrophotometric determination, pharmaceutical preparations
Como citar
Farmaco. Lausanne: Elsevier B.V. Sa, v. 54, n. 9, p. 629-635, 1999.