Effects of Low Molecular Weight Sulfated Galactan Fragments From Botryocladia Occidentalis on the Pharmacological and Enzymatic Activity of Spla2 From Crotalus Durissus Cascavella
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Data
2010-11-01
Autores
Toyama, M. H. [UNESP]
Toyama, D. O.
Torres, V. M.
Pontes, G. C.
Farias, W. R. L.
Melo, F. R.
Oliveira, S. C. B. [UNESP]
Fagundes, F. H. R. [UNESP]
Diz Filho, E. B. S. [UNESP]
Cavada, B. S.
Título da Revista
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Título de Volume
Editor
Springer
Resumo
Low molecular weight fragments of sulfated galactans (Boc-5 and Boc-10) from the red algae Botryocladia occidentalis significantly inhibited Crotalus durissus cascavella sPLA2 enzymatic activity. Equimolar ratios of sPLA2 to Boc-5 or Boc-10 resulted in allosteric inhibition of sPLA2. Under the conditions tested, we observed that both Boc-5 and Boc-10 strongly decreased edema, myonecrosis, and neurotoxicity induced by native sPLA2.
Descrição
Palavras-chave
Botryocladia occidentalis, Crotalus durissus cascavella, Secretory phospholipase A2 (sPLA2), Edema, Myonecrosis
Como citar
Protein Journal. New York: Springer, v. 29, n. 8, p. 567-571, 2010.