Composites PVDF-TrFE/BT used as bioactive membranes for enhancing bone regeneration
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Data
2004-01-01
Autores
Gimenes, R.
Zaghete, M. A.
Bertolini, M.
Varela, José Arana [UNESP]
Coelho, L. O.
Silva, N. F.
Título da Revista
ISSN da Revista
Título de Volume
Editor
Spie - Int Soc Optical Engineering
Resumo
In this paper a piezoelectric composite membranes were developed for charge generator to promoter bone regeneration on defects sites. Is known that the osteogenesis process is induced by interactions between biological mechanisms and electrical phenomena. The membranes were prepared by mixing Barium Titanate (BT) powders and PVDF-TrFE (PVDF:TrFE = 60:40 mol%) on dimethylformamide medium. This precursor solution was dried and crystallized at 100degreesC for 12 hours. Composites membranes were obtained by following methods: solvent casting (SC), spincoating (SP), solvent extraction by water addition (WS) and hot pressing (HP).The microstructural analysis performed by SEM showed connectivity type 3-0 and 3-1 with high homogeneity for samples of ceramic volume fraction major than 0.50. Powder agglomerates within the polymer matrix was evidenced were observed for composites with the BT volume fraction major than 40%. The composite of ceramic fraction of 0.55 presented the best values of remanent polarization (similar to33 muC/cm(2)), but the flexibility of these composites with the larger ceramic fraction was significantly affected.For in vivo evaluation PVDF-TrFE/BT 90/10 membranes with 3cm larger were longitudinally implanted under tibiae of male rabbit. After 21 days the animals were sacrificed. By histological analyses were observed neo formed bone with a high mitotic activity. In the interface bone-membrane was evidenced a pronounced callus formation. These results encourage further applications of these membranes in bone-repair process.
Descrição
Palavras-chave
copolymer (PVDF-TrFE), bio-active membrane, bone promoter, barium titanate, ferroelectric composites
Como citar
Smart Structures and Materials 2004: Electroactive Polymer Actuators and Devices (eapad). Bellingham: Spie-int Soc Optical Engineering, v. 5385, p. 539-547, 2004.