Limonoids showing selective toxicity to DNA repair-deficient yeast and other constituents of Trichilia emetica
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Data
1998-02-01
Autores
Gunatilaka, AAL
Bolzani, Vanderlan da Silva [UNESP]
Dagne, E.
Hofmann, G. A.
Johnson, R. K.
McCabe, F. L.
Mattern, M. R.
Kingston, DGI
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Amer Chemical Soc
Resumo
Bioactivity-directed fractionation of the MeCOEt extract of Trichilia emetica (Meliaceae) resulted in the isolation of the limonoids nymania 1 (1), drageana 4 (3), trichilin A (4), rohituka 3 (5),and Tr-B (7) and the novel seco-A protolimonoid 8. of these, nymania 1 and Tr-B showed selective inhibitory activity toward DNA repair-deficient yeast mutants. The isolation, structure elucidation, C-13 NMR spectral assignments, and biological activities of:these compounds are reported.
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Journal of Natural Products. Washington: Amer Chemical Soc, v. 61, n. 2, p. 179-184, 1998.