Repeated administration intensifies the reinforcing effect of fencamfamine in rats
Nenhuma Miniatura disponível
Data
1997-08-01
Autores
DeLucia, R.
Planeta, Cleopatra da Silva [UNESP]
Aizenstein, M. L.
Scavone, C.
Título da Revista
ISSN da Revista
Título de Volume
Editor
Elsevier B.V.
Resumo
1. In the present study, we evaluated the role of repeated administration on conditioning place preference (CPP) induced by fencamfamine (FCF) in male rats.2. Repeated FCF (3.5 mg/kg) or saline once or daily for ten consecutive days enhanced sniffing du ration and decreased locomotion and rearing duration.3. At the 3.5 mg/kg dose, FCF produced a significant place-preference effect.4. Repeated exposures to FCF intensified its reinforcing properties.5. These results suggest that repeated FCF administration sensitizes its rewarding effects, as with other addictive substances. GEN PHARMAC 29;2:265-261, 1997. (C) 1997 Elsevier B.V.
Descrição
Palavras-chave
fencamfamine, psychostimulant, sensitization, place conditioning, reinforcing effect
Como citar
General Pharmacology. Oxford: Pergamon-Elsevier B.V., v. 29, n. 2, p. 265-267, 1997.