The proliferating cell nuclear antigen index in breast carcinomas does not correlate with mitotic index and estrogen receptor immunoreactivity
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Data
1994-09-01
Autores
Schmitt, F. C.
Pereira, E. M.
Andrade, L. M.
Torresan, M.
Delucca, L.
Título da Revista
ISSN da Revista
Título de Volume
Editor
Gustav Fischer Verlag
Resumo
To investigate the expression of a marker of cell proliferation (PCNA/Cyclin) and its putative relationship with histological grading, mitotic index and estrogen receptor immunoreactivity, we studied twenty-seven cases of invasive breast carcinoma in formalin-fixed, paraffin-embedded tissue sections. The PCNA and estrogen receptor were detected by the PC10 and H222 monoclonal antibodies respectively, using an avidin-biotin-pernxidase method. The median value of PCNA index was 20.9% with a range from 1.4 to 84.2%. We did not find any significant relationship between PCNA index anti the histological grading, mitotic index and estrogen receptor immunoreactivity. We conclude that PCNA detected by the monoclonal antibody PC10 in formalin-fixed material looks at present unrealiable as a proliferation marker in breast carcinoma.
Descrição
Palavras-chave
PROLIFERATIVE CELL NUCLEAR ANTIGEN, PC10, ESTROGEN RECEPTOR, BREAST CANCER
Como citar
Pathology Research and Practice. Jena: Gustav Fischer Verlag, v. 190, n. 8, p. 786-791, 1994.