Antifungal amide from leaves of Piper hispidum
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Data
1998-05-01
Autores
Alecio, A. C.
Bolzani, Vanderlan da Silva [UNESP]
Young, MCM
Kato, M. J.
Furlan, Maysa [UNESP]
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Amer Chemical Soc
Resumo
Bioactivity-guided fractionation of a CH2Cl2 extract from leaves of Piper hispidum (Piperaceae) yielded a new pyrrolidine amide, N-[7-(3',4'-methylenedioxyphenyl)-2(Z),4(Z)-heptadienoyl] pyrrolidine 1, in addition to two known amides N-[5-(3',4'-methylenedioxyphenyl)-2(E)-pentadienoyl]pyrrolidine and N-[2-(3',4'-methylenedioxy-6'-methoxyphenyl)-2(Z)-propenoyl]pyrrolidine. The structure of compound 1 was elucidated by interpretation of spectral data, including ES-MS. Compound 1 showed antifungal activity against Cladosporium sphaerospermum.
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Journal of Natural Products. Washington: Amer Chemical Soc, v. 61, n. 5, p. 637-639, 1998.