Chronic Suppurative Otitis Media in Cleft Palate: Microorganism Etiology and Susceptibilities
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Data
2009-09-01
Autores
Weckwerth, Paulo Henrique
de Magalhaes Lopes, Carlos Alberto [UNESP]
Hungaro Duarte, Marco Antonio
Villas Boas Weckwerth, Ana Carolina
Ferreira Martins, Carlos Henrique
Lamonica Neto, Domingos
de Aguiar, Heider Fernandes
Título da Revista
ISSN da Revista
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Editor
Alliance Communications Group Division Allen Press
Resumo
Objective: To investigate the microbial etiology of suppurative chronic otitis media (SCOM) in patients with complete cleft lip and palate and isolated cleft palate and to determine the sensitivity of isolated microorganisms to antibiotics by drug diffusion from impregnated discs in agar and the minimum inhibitory concentration of each drug to these microorganisms by drug dilution in agar.Design/Patients: Effusion samples of SCOM obtained from 40 patients with cleft lip and palate registered at the Hospital for Rehabilitation of Craniofacial Anomalies, University of São Paulo, at Bauru, Brazil, were bacteriologically analyzed by cultures. The isolated bacteria were submitted to an in vitro susceptibility test to clinically used drugs.Results: Positive cultures were obtained in 100% of studied cases. Among the 57 strains observed, the most frequent were Pseudomonas aeruginosa (35%), Staphylococcus aureus (15.5%), Enterococcus faecalis (14%), and Proteus mirabilis (12%). The frequency of Gram-negative bacilli (enterobacteriaceae and nonfermentative bacilli) was 67%. Pseudomonas aeruginosa presented the highest sensitivity to ciprofloxacin, and enterobacteriaceae exhibited the highest sensitivity to gentamicin. The strains of S. aureus and E. faecalis presented the highest sensitivity to imipenem and sulfamethoxazole/trimethoprim, respectively.Conclusion: Patients with cleft lip and palate presenting with SCOM exhibited 100% positive cultures, with the highest frequency of Pseudomonas and enterobacteriaceae. With regard to the action of antibiotics, imipenem was effective against the four species of isolated microorganisms, followed by ciprofloxacin, which was effective against 75% of isolated species.
Descrição
Palavras-chave
cleft lip, cleft palate, drug susceptibility, microbiology, suppurative chronic otitis media
Como citar
Cleft Palate-craniofacial Journal. Lawrence: Alliance Communications Group Division Allen Press, v. 46, n. 5, p. 461-467, 2009.