Proteome analysis of snake venom toxins: pharmacological insights
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Data
2008-12-01
Autores
Georgieva, Dessislava
Arni, Raghuvir K. [UNESP]
Betzel, Christian
Título da Revista
ISSN da Revista
Título de Volume
Editor
Expert Reviews
Resumo
Snake venoms are an extremely rich source of pharmacologically active proteins with a considerable clinical and medical potential. To date, this potential has not been fully explored, mainly because of our incomplete knowledge of the venom proteome and the pharmacological properties of its components, in particular those devoid of enzymatic activity. This review summarizes the latest achievements in the determination of snake venom proteome, based primarily on the development of new strategies and techniques. Detailed knowledge of the venom toxin composition and biological properties of the protein constituents should provide the scaffold for the design of new more effective drugs for the treatment of the hemostatic system and heart disorders, inflammation, cancer and consequences of snake bites, as well as new tools for clinical diagnostic and assays of hemostatic parameters.
Descrição
Palavras-chave
pharmacological activity, proteomics, Snake venom, Toxin, venom protein family
Como citar
Expert Review of Proteomics. London: Expert Reviews, v. 5, n. 6, p. 787-797, 2008.