Effect of the dibenzylbutyrolactone lignan (-)-hinokinin on doxorubicin and methyl methanesulfonate clastogenicity in V79 Chinese hamster lung fibroblasts
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Data
2010-07-19
Autores
Resende, Flavia Aparecida [UNESP]
Tomazella, Iara Maluf
Barbosa, Lilian Cristina
Ponce, Marina
Furtado, Ricardo Andrade
Pereira, Ana Carolina
Bastos, Jairo Kenupp
Andrade e Silva, Marcio Luis
Tavares, Denise Crispim
Título da Revista
ISSN da Revista
Título de Volume
Editor
Elsevier B.V.
Resumo
The dibenzylbutyrolactone lignan (-)-hinokinin (HK) was obtained by partial synthesis from (-)-cubebin, isolated from the dry seeds of the pepper, Piper cubeba. In view of the trypanocidal activity of HK and its potential as a lead compound for drug development, evaluation of its possible genotoxic activity is required. We have tested HK for possible genotoxicity and evaluated the compound's effect on the activity of the clastogens doxorubicin (DXR) and methyl methanesulfonate (MMS) in the micronucleus (MN) assay with Chinese hamster lung fibroblast V79 cells. HK alone did not induce MN, at concentrations up to 128 mu M. In combined treatments, HK reduced the frequency of MN induced by MMS. With respect to DXR, HK exerted a protective effect at lower concentrations, but at higher concentrations it potentiated DXR clastogenicity. (C) 2010 Elsevier B.V. All rights reserved.
Descrição
Palavras-chave
Hinokinin, Micronucleus, V79 cell, Clastogenicity
Como citar
Mutation Research-genetic Toxicology and Environmental Mutagenesis. Amsterdam: Elsevier B.V., v. 700, n. 1-2, p. 62-66, 2010.