Observations on the development of the febrile response to pyrogen in newborn pigs
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Data
1985-12-01
Autores
Moraes, R. N.
Macari, Marcos [UNESP]
Pela, I. R.
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Resumo
The febrile response of newborn pigs to exogenous pyrogen injection was investigated. Lipopolysacharides (LPS, E coli) were injected intravenously into the superior vena cava of 1-30-day-old piglets. All the experiments were carried out in littermates half of which were injected with pyrogen and half with pyrogen-free saline. Newborn pigs did not develop a febrile response from 1 to 4 days of age; however, when the animals were 5 days old exogenous pyrogen determined a typical monophasic febrile response. A second intravenous injection of pyrogen into newborn pigs (1 day old) 24 h after the first did not raise body temperature. It is suggested that newborn pigs behave like the newborn of other mammalian species regarding endotoxin-induced thermogenesis.
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endotoxin, lipopolysaccharide, pyrogen, animal experiment, fever, newborn, nonhuman, priority journal, swine, thermogenesis, Aging, Animal, Animals, Newborn, Escherichia coli, Fever, Kinetics, Lipopolysaccharides, Support, Non-U.S. Gov't, Swine
Como citar
Biology of the Neonate, v. 48, n. 5, p. 307-312, 1985.