Cold-acclimation improves cold-tolerance of diabetic rats
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Data
1987-12-01
Autores
Ferro, Jesus A
Macari, Marcos [UNESP]
Eizirik, Décio L
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Resumo
1. 1. The aim of these experiments was to study the extent to which previous cold-acclimation improves the cold-tolerance of diabetic rats. 2. 2. Alloxan diabetic rats (fasting blood glucose higher than 200mg/dl) were used in the experiments. 3. 3. In Expt. 1, non-cold-acclimated control and diabetic rats were exposed to cold environment (7-9°C), and the percentage of survival calculated during a 12-day experimental period. In Expt. 2, the rats were previously cold-acelimated before alloxan or saline injection (diabetic and control cold-acclimated rats) and the survival rate was also assessed during a 12-day period in the cold. 4. 4. The percentage of survival of the non-cold-acclimated diabetic rats (Expt.l) was 19% compared with 79% of the diabetic cold-acclimated animals (Expt. 2). There were no deaths in the control groups. 5. 5. Cold-acclimated diabetic rats maintained a near-normal thermogenic response after noradrenaline injection. This response was impaired in non-cold-acclimated diabetic rats. 6. 6. The results of these experiments suggest that the enhanced cold-tolerance of diabetic cold-acclimated rats could be related to the increased sympathetic activity and enhanced insulin sensitivity in thermogenic tissues, such as brown fat. © 1987.
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noradrenalin, acclimatization, animal, body weight, cold, comparative study, drug effect, experimental diabetes mellitus, male, pathophysiology, rat, rat strain, reference value, thermoregulation, time, Acclimatization, Animal, Body Temperature Regulation, Body Weight, Cold, Comparative Study, Diabetes Mellitus, Experimental, Male, Norepinephrine, Rats, Rats, Inbred Strains, Reference Values, Support, Non-U.S. Gov't, Time Factors
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Comparative Biochemistry and Physiology -- Part A: Physiology, v. 88, n. 3, p. 425-429, 1987.