Experimental surgery of the facial nerve. Assessment of the intraperitoneal use of exogenous gangliosides
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Data
1995-01-01
Autores
Montovani, Jair Cortez [UNESP]
Prado, R. G. [UNESP]
Bacchi, C. E. [UNESP]
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Resumo
Compression and section of the facial nerve were performed in 48 rats in order to study the anatomopathological alterations occurring after daily intraperitoneal injections of 100 mg of exogenous gangliosides (Sinaxial®) for 45, 90, 180 days. In groups submitted to nerve compression, the histopathological changes were discrete and in the 180-day subgroups the nerve was practically normal. In animals submitted to section and neurorrhaphy there was formation of an amputation neuroma, a granuloma around the suture, axonal unstructuration and inter and perineural fibrosis. No significant differences were observed between the groups submitted or not to injection of exogenous gangliosides, indicating that the major factors involved in the quality of nerve regeneration were the technique and the formation of fibrosis and of an amputation neuroma.
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Palavras-chave
facial nerve, gangliosides, ganglioside, sinaxial, unclassified drug, animal experiment, animal tissue, controlled study, facial nerve disease, histopathology, intraperitoneal drug administration, male, nerve compression, nerve regeneration, nonhuman, rat, animal, pathology, physiology, Animal, English Abstract, Facial Nerve, Gangliosides, Injections, Intraperitoneal, Male, Nerve Regeneration, Rats
Como citar
Revue de Laryngologie Otologie Rhinologie, v. 116, n. 3, p. 163-167, 1995.