Functional evidence that the central renin-angiotensin system plays a role in the pressor response induced by central injection of carbachol
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Data
1997-04-01
Autores
Saad, William A. [UNESP]
Luiz, A. C. [UNESP]
Camargo, L. A A [UNESP]
Silveira, J. E N [UNESP]
Fóglia, S. [UNESP]
Menani, José Vanderlei [UNESP]
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Resumo
We investigated the effects of losartan, an AT 1-receptor blocker, and ramipril, a converting enzyme inhibitor, on the pressor response induced by angiotensin II (ANG II) and carbachol (a cholinergic receptor agonist). Male Holtzman rats (250-300 g) with a stainless steel cannula implanted into the lateral ventricle (LV) were used. The injection of losartan (50 nmol/l μl) into the LV blocked the pressor response induced by ANG II (12 ng/l μl) and carbachol (2 nmol/l μl). After injection of ANG II and carbachol into the LV, mean arterial pressure (MAP) increased to 31 ± 1 and 28 ± 2 mmHg, respectively. Previous injection of losartan abolished the increase in MAP induced by ANG II and carbachol into the LV (2 ± 1 and 5 ± 2 mmHg, respectively). The injection of ramipril (12 ng/l μl) prior to carbachol blocked the pressor effect of carbachol to 7 ± 3 mmHg. These results suggest an interaction between central cholinergic pathways and the angiotensinergic system in the regulation of arterial blood pressure.
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carbachol, central angiotensin, pressor response, angiotensin, losartan, losartan potassium, ramipril, animal experiment, cholinergic system, conference paper, controlled study, intracerebroventricular drug administration, male, nonhuman, rat, renin angiotensin aldosterone system, Angiotensin-Converting Enzyme Inhibitors, Animals, Blood Pressure, Carbachol, Cerebral Ventricles, Cholinergic Agonists, Losartan, Male, Pressoreceptors, Ramipril, Rats, Rats, Sprague-Dawley, Receptors, Angiotensin, Renin-Angiotensin System, Animalia
Como citar
Brazilian Journal of Medical and Biological Research, v. 30, n. 4, p. 493-496, 1997.