Avaliação bioquímica do extrato etanólico de própolis em ratos
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Data
2002-12-01
Autores
Fernandes, Ana Angélica Henrique [UNESP]
Sinzato, Sandra [UNESP]
Kato, Heloisa Hideko Nakaghi [UNESP]
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Resumo
Propolis is a natural product collected by honey bees containing, among other biochemical constituents, a variety of flavonoids. Propolis is a folk medicinal employed for treating various diseases. It is alleged to exhibit a broad spectrum of bioactivities. The aim of this study was to evaluate the effect of ethanolic extract of propolis (EEP) of species Plebeia droryana and Scaptotrigonea bipunctata through biochemical parameters. Rats were divided into 4 groups: (G1) untreated; (G2) ethanol treated; (G3) treated EEP of Plebeia droryana; (G4) treated of Scaptotrigonea bipunctata. The EEP (100 mg/kg b. w., daily) was administered orally to the animals, for 30 days. Treatment with EEP for two species showed reduction (p<0,05) in serum alanine aminotransferase, aspartato aminotransferase and alkaline phosphatase activity, compared to control ethanol values. The administration of EEP lowered significantly the serum levels of cholesterol (G3= 48,83±5,7 mg/dL; G4=56,91±6,5 mg/dL) and triacylglycerol (G3=45,17±4,16 mg/dL; G4=46,74± 3,90 mg/dL). The serum concentration of albumin (G3=4,16±0,6 g/dL; G4= 3,61±0,36 g/dL) increased (p<0,05) after the administration of EEP, however, it did not affect total protein and glucose concentration. The data suggest that EEP of two species caused alterations of the biochemical parameters.
Descrição
Palavras-chave
Biochemical parameters, Piebeia droryana, Própoiis, Scaptotrigonea bipunctata, alanine aminotransferase, albumin, alcohol, alkaline phosphatase, cholesterol, flavonoid, glucose, propolis, protein, triacylglycerol, albumin blood level, animal cell, animal experiment, animal model, animal tissue, biochemistry, cholesterol blood level, controlled study, drug activity, extraction, glucose blood level, honeybee, male, nonhuman, plebeia droryana, rat, scaptotrigonea bipunctata, species identification, statistical analysis, statistical significance, traditional medicine
Como citar
Revista de Ciencias Farmaceuticas, v. 23, n. 1, p. 97-109, 2002.