Doença arterial coronariana: Um novo paradigma na AIDS
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Data
2004-12-01
Autores
Malavazi, I. [UNESP]
Abrão, E. P. [UNESP]
Mikawa, A. Y. [UNESP]
Landgraf, V. O. [UNESP]
Costa, P. I. [UNESP]
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Resumo
The HIV-infected individuals have been identified as a peculiar group whose propensity to the development of abnormalities in lipids metabolism supports the hypothesis that AIDS itself can be considered as an independent risk factor for the occlusive diseases development. The AIDS progression, as well as the therapy against HIV has been capable to show an array of metabolic disturbances that HIV-infected patients are prone to. These metabolic alterations affect the fate of plasmatic lipids and homocysteine as a result of three factor mainly: (i) the viral infection per se which triggers the development of hypertriglyceridemia and hipocholesterolemia; (ii) multiple vitamins and micronutrients deficiencies, that favors an onset of hyperhomocysteinemia; (iii) the state-of-the-art therapy for HIV infection, which is accompanied to idiosyncratic effects encompassing the lipid metabolism. In this context, a variety of risk factors to atherosclerosis can be identified in the HIV-infected individual. Of note, it must be considered that once life expectancy of these patients has been expanded due to the effective therapy, on the other hand they can accelerate atherosclerotic disease or its pathological appearance in the same extent.
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Palavras-chave
Antiretroviral, Apolipoproteins, HAART, HIV, Homocysteine, Lipoproteins, antiretrovirus agent, cytochrome P450 3A, didanosine, high density lipoprotein, homocysteine, lipid, low density lipoprotein, peroxisome proliferator activated receptor gamma, retinoid X receptor, RNA directed DNA polymerase inhibitor, very low density lipoprotein, zalcitabine, zidovudine, acquired immune deficiency syndrome, atherosclerosis, coronary artery disease, disease course, highly active antiretroviral therapy, human, Human immunodeficiency virus, Human immunodeficiency virus infection, hyperhomocysteinemia, hypertriglyceridemia, hypocholesterolemia, life expectancy, lipid metabolism, metabolic disorder, nonhuman, pathology, review, virus infection, vitamin deficiency
Como citar
Revista de Ciencias Farmaceuticas, v. 25, n. 2, p. 69-78, 2004.