Evaluation of Strychnos pseudoquina St. Hil. leaves extract on gastrointestinal activity in mice
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Data
2005-08-01
Autores
Aparecido Da Silva, Marcelo [UNESP]
Murino Rafacho, Bruna Paola [UNESP]
Hiruma-Lima, Clelia Akiko [UNESP]
Machado Da Rocha, Lúcia Regina [UNESP]
Campaner Dos Santos, Lourdes [UNESP]
Sannomiya, Miriam [UNESP]
Monteiro Souza-Brito, Alba Regina
Vilegas, Wagner [UNESP]
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Resumo
Strychnos pseudoquina St. Hil. (Loganiaceae) was investigated for its ability to protect the gastric mucosa against injuries caused by non-steroidal anti-inflammatory drugs (piroxicam) and a necrotizing agent (HCl/EtOH) in mice. The MeOH extract and enriched alkaloidic fraction (EAF) provided significant protection in experimental models wheer used at doses of 250 and 1000 mg/kg. In vivo tests were carried out to evaluate for possible toxic effects and no mortality was observed up to the 5 g/kg dose level. Phytochemical investigation led to the isolation of a new indole alkaloid, which elucidated the observed pharmacological effects. © 2005 Pharmaceutical Society of Japan.
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Alkaloid, Antiulcer activity, Strychnos pseudoquina, Toxic activity, piroxicam, plant extract, strychnos pseudoquina extract, unclassified drug, animal experiment, animal model, animal tissue, concentration response, controlled study, drug dose regimen, drug effect, drug isolation, drug screening, in vivo study, male, medicinal plant, mortality, mouse, nonhuman, phytochemistry, plant leaf, stomach mucosa, stomach protection, stomach ulcer, strychnos pseudoquina, Animals, Anti-Inflammatory Agents, Non-Steroidal, Drug Evaluation, Preclinical, Gastric Mucosa, Mice, Plant Extracts, Plant Leaves, Stomach Ulcer, Strychnos
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Chemical and Pharmaceutical Bulletin, v. 53, n. 8, p. 881-885, 2005.