O emprego de hormônio luteinizante recombinante associado ao hormônio folículo-estimulante recombinante nos protocolos de estimulação ovariana com antagonista do GnRH
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Data
2006-10-01
Autores
Baruffi, Ricardo L.R.
Mauri, Ana L. [UNESP]
Petersen, Cláudia G. [UNESP]
Felipe, Valéria
Martins, Anice M.C. [UNESP]
Cornicelli, João
Cavagna, Mario
Oliveira, João B.A.
Franco Junior, Jose Gonçalves [UNESP]
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Resumo
The purpose of this investigation was to verify the efficacy of recombinant LH supplementation for controlled ovarian stimulation in GnRH-antagonist protocol for assisted reproductive technologies cycles. Search strategies included on-line surveys of databases from 1990 to 2006. In this review and meta-analysis, the observed advantages for the LH supplementation protocol were a higher serum estradiol levels on the day of hCG administration and a higher number of mature oocytes. However, there were no differences observed in the total amount of r-FSH administered, days of stimulation, number of oocyte retrieved, the clinical pregnancy rate per oocyte retrieval, the implantation rate and miscarriage rate. This result demonstrates that the association of r-LH with r-FSH may prevent any decrease in estradiol after antagonist administration and a significant higher number of mature oocytes was obtained. Nevertheless, additional randomized controlled trials are needed confirm these observations.
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GnRH antagonist, Ovarian stimulation, Recombinant FSH, Recombinant LH, cetrorelix, chorionic gonadotropin, estradiol, ethinylestradiol, ethinylestradiol plus gestodene, gonadorelin antagonist, levonorgestrel, oral contraceptive agent, recombinant follitropin, recombinant luteinizing hormone, clinical trial, combination chemotherapy, data base, drug dose regimen, drug efficacy, drug mechanism, estradiol blood level, hormone substitution, human, low drug dose, meta analysis, monotherapy, oocyte, ovary function, pregnancy rate, spontaneous abortion, systematic review
Como citar
Jornal Brasileiro de Reproducao Assistida, v. 10, n. 4, p. 9-16, 2006.