Vernonia polyanthes as a new source of antiulcer drugs
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Data
2007-12-01
Autores
Barbastefano, Victor
Cola, Maira
Luiz-Ferreira, Anderson
Farias-Silva, Elisângela
Hiruma-Lima, Clélia A. [UNESP]
Rinaldo, Daniel [UNESP]
Vilegas, Wagner [UNESP]
Souza-Brito, Alba R.M.
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Resumo
Methanolic (VPME) and chloroformic (VPCL) extracts, obtained from the aerial parts of Vernonia polyanthes, were investigated for its antiulcerogenic properties. Administration of VPME (250 mg/kg) and VPCL (50 mg/kg) significantly inhibited the gastric mucosa damage (64% and 90%, respectively) caused by absolute ethanol (p.o.). Otherwise, in NSAID-induced gastric damage, their gastroprotective effects have decreased. Since the VPCL extract resulted to be more effective than the VPME we focused our efforts over VPCL action mechanism of action. © 2007 Elsevier B.V. All rights reserved.
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Action mechanisms, Antiulcerogenic activity, Vernonia polyanthes, alcohol, antiulcer agent, carbenoxolone, cimetidine, lansoprazole, n ethylmaleimide, n(g) nitroarginine methyl ester, nonsteroid antiinflammatory agent, piroxicam, plant extract, unclassified drug, vernonia polyanthes chloroformic extract, Vernonia polyanthes extract, vernonia polyanthes methanolic extract, animal experiment, animal model, drug inhibition, drug mechanism, male, medicinal plant, mouse, nonhuman, priority journal, rat, stomach mucosa lesion, vernonia polyanthes, Animals, Anti-Inflammatory Agents, Non-Steroidal, Anti-Ulcer Agents, Dose-Response Relationship, Drug, Ethanol, Male, Phytotherapy, Plant Components, Aerial, Plant Extracts, Rats, Rats, Wistar, Stomach Ulcer, Vernonia
Como citar
Fitoterapia, v. 78, n. 7-8, p. 545-551, 2007.