Análise das dosagens e concentrações séricas da ciclosporina A em cães da raça Golden Retriever normais ou afetados pela distrofia muscular
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Data
2008-12-01
Autores
Morini, Adriana Caroprezo
Miglino, Maria Angélica
Carvalho, Marileda Bonafim [UNESP]
Martins, Daniele Dos Santos
Ambrósio, Carlos Eduardo
de Oliveira, Lílian Jesus
Catelli, Alida Abatemarco
Souza, Ana Paula [UNESP]
Kfoury Junior, José Roberto
Luppi, Martha Maria Circhia Pinto
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Resumo
The muscular dystrophy of Golden Retriever (GRMD) is a degenerative miopaty caused by the absence of dystrophy and it is genetically homologue of the Duchenne muscular dystrophy in humans, so, these dogs are considerably experimental models for studies on cellular therapy. Their successful depends of the adequate immunosuppression. Cyclosporin A (CsA) is indicated for that and the monitoring of the blood concentration and adverse effects are essential to viabilise the therapy. It was studied GRMD dogs, and normal dogs from the same breed, submitted for therapy with CsA, associated, on GRMD, of cell transplantation. It was evaluated blood concentration of the drug, between two or tree days using the method of FPIA. In our results we found that the CsA blood concentrations oscillated too much on six than eight of our animals. We concluded that the doses varieties individually and the correct dosage as to important as the evaluation of the blood concentration of the drug and became viable for cell therapy.
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Blood concentration, Fluorescence polarization immunoassay (FPIA), Golden Retriever muscular dystrophy, Immunosuppression, Animalia, Canis familiaris
Como citar
Brazilian Journal of Veterinary Research and Animal Science, v. 45, n. 2, p. 131-137, 2008.